CANCER BIOLOGY

    The company deliver services for the assessment of potential anti-cancer molecules using several in-vivo animal modelsincluding Xenograft, Syngeneic, angiogenesis and Orthotopicmodels. We have cell line repositories of different human cancer cells used for the cancer biology, validating cancer targets and for defining drug efficacy.

interior-img

XENOGRAFT MOUSE MODELS

Following xenograft models are carried out at in-vivo oncology facility

  1. HCT116 : Human colorectal carcinoma
  2. MIA PaCa-2 : Human pancreatic cancer
  3. MOLT-4 : T lymphoblast; acute lymphoblastic leukemia
  4. A2780 : Human ovarian adenocarcinoma
  5. A549 : Human alveolar cell carcinoma
  6. SK-MEL-2 :Human Melanoma Cell Line
  7. MDA-MB-231 : Triple-negative breast canceradenocarcinoma

SYNGENIEC MOUSE MODELS

    Our cancer biology domain also has animal cancer lines to run syngeneic mouse models study.

    1. CT26 : Murine colorectal carcinoma
    2. B16F10 : Murine melanoma

MATRIGEL PLIG ASSAYS

We also provide service for the testing of potential angiogenic inhibitor molecules.

  1. Matrigel Plug assay in athymic nude mice

ORTHOTOPIC MOUSE MODELS

Orthotopic mouse model includes

  1. MDA-MB-231 : Triple-negative breast canceradenocarcinoma
  2. B16-F10 : Murine melanoma

TOXICOLOGY

interior-img

GENERAL TOXICITY

Acute Toxicity

  1. Acute Oral Toxicity- OECD Test No- 423
  2. Acute Dermal Toxicity- OECD Test No-402
  3. Acute Inhalation Toxicity- OECD Test No-403
  4. Acute Eye Irritation/Corrosion- OECD Test No-405
  5. Acute Dermal Irritation/Corrosion- OECD Test No-404
  6. Skin Sensitization(Guinea Pig Maximisation Test and Buehler Testand Buehler Test)- OECD Test No-406

REPEATE DOSE/SUB-ACUTE TOXICITY

  1. Repeated Dose 28-day Oral Toxicity Study in Rodents-OECD Test No. 407
  2. Repeated Dose 90-Day Oral Toxicity Study in Rodents- OECD Test No. 408
  3. Repeated Dose Dermal Toxicity- 21/28-day Study- OECD Test No. 410
  4. Sub-chronic Dermal Toxicity- 90-day Study- OECD Test No. 411

REPRODUCTION/ DEVELOPMENT TOXICITY

  1. Chronic Toxicity: 12-Month Study-OECD Test No. 452
  2. Reproduction/Developmental Toxicity Screening Test- OECD Test No. 421
  3. Prenatal Developmental Toxicity Study- OECD Test No. 414
  4. One-Generation Reproduction Toxicity Study- OECD Test No. 415
  5. Two-Generation Reproduction Toxicity-OECD Test No. 416
  6. Extended One-Generation Reproductive Toxicity Study- OECD Test No. 443

CHRONIC TOXICITY

  1. Chronic Toxicity: 12-Month Study-OECD Test No. 452

GENOTOXICITY/MUTAGENICITY

IN-VITRO MODELS

  1. Bacterial Reverse Mutation Test Ames Test- OECD Test No. 471
  2. Mammalian Chromosomal Aberration Test- OECD Test No. 473
  3. In Vitro Mammalian Cell Micronucleus Test- OECD Test No. 487

IN-VIVO MODELS

  1. Anti-Malarial
  2. Mammalian Erythrocyte Micronucleus Test- Test No. OECD 474
  3. Mammalian Erythrocyte Micronucleus Test- Test No. OECD 474

CELL BIOLOGY

interior-img

CELL BASED ASSAYS

  1. MTT Assay
  2. SRB Assay
  3. COX Activity Assay
  4. NF-kB Assay
  5. Lipid Peroxidation
  6. α-amylase Inhibition Assay
  7. α -glucosidase Inhibition Assay

BIOMAKERS ESTIMATIONS

    1. Weoffer services for the cytokines estimation in blood serum/plasma,
      &/or tissue homogenate, as per the Client’s research needs

Pro-inflammatory Cytokines

  1. TNF-α
  2. IL-6
  3. IL-1β

ANTI-OXIDANT PROFILING

  1. DPPH radical scavenging activity
  2. Nitric oxide radical scavenging activity
  3. Hydroxyl radical scavenging activity
  4. Lipid Peroxidation by TBARS method
  5. Superoxide radical scavenging activity
  6. Estimation of anti-oxidative components

ANTI-INFLAMMATORY CYTOKINES

  1. (IL)-1 receptor antagonist
  2. IL-4
  3. IL-10, & IL-13